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Quality products?make an important contribution to long-term revenue and profitability. Factory supply Ethyl S-4-chloro-3-hydroxybutyrate 86728-85-0 with sufficient stock and high standard
1.What is the Ethyl S-4-chloro-3-hydroxybutyrate ?
Ethyl (S)-(?)-4-chloro-3-hydroxybutyrate can be used as a starting material in the synthesis of 4-amino-3-hydroxybutyric acid, a compound of pharmacological importance.
-
-
638-07-3
ethyl (2-chloroaceto)acetate
-
-
10488-69-4,86728-85-0,87068-18-6,90866-33-4
ethyl (S)-4-chloro-3-hydroxybutanoate
Conditions
| Conditions | Yield |
|---|---|
|
With
formic acid; NAD; sodium formate;
formate dehydrogenase;
In
water;
at 30 ℃;
for 3.5h;
pH=6.5;
|
100% |
|
With
Escherichia coli BL21 (fdh, adh)-cells;
In
water;
for 1h;
pH=6.5;
|
99.3% |
|
With
hydrogen;
(R)-[RuCl2(BINAP)]n;
In
ethanol;
at 95 - 105 ℃;
for 0.5 - 8h;
under 67506.8 - 75007.5 Torr;
Conversion of starting material;
|
98% |
|
With
isopropyl alcohol; NADH;
In
aq. phosphate buffer;
at 30 ℃;
pH=6.5 - 7;
enantioselective reaction;
Microbiological reaction;
Enzymatic reaction;
|
98.5% |
|
With
potassium phosphate buffer; Lactobacillus kefir DSMZ 20587; isopropyl alcohol;
magnesium chloride;
at 30 ℃;
for 14h;
pH=6.5;
|
97% |
|
With
hydrogen; triethylamine;
dichloro(1,5-cyclooctadiene)ruthenium(II); (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl;
In
ethanol;
at 100 ℃;
under 77572.2 Torr;
|
96% |
|
With
triethanolamine; D-glucose; sulfuric acid; β-nicotinamide adenine dinucleotide phosphate sodium salt; sodium hydroxide;
In
acetic acid butyl ester;
at 25 ℃;
for 8h;
pH=6.9;
optical yield given as %ee;
enantioselective reaction;
Enzymatic reaction;
|
96% |
|
With
D-glucose;
In
ethanol;
at 25 ℃;
for 0.25h;
pH=6.8;
Reagent/catalyst;
optical yield given as %ee;
enantioselective reaction;
Kinetics;
Microbiological reaction;
aq. phosphate buffer;
|
96% |
|
With
recombinant E. coli cells coexpressing carbonyl reductase and glucose dehydrogenase on cell surface;
In
aq. phosphate buffer; dibutyl ether;
at 20 ℃;
for 10.5h;
pH=6.5;
|
96% |
|
With
β-nicotinamide adenine dinucleotide phosphate disodium; isopropyl alcohol; magnesium chloride;
In
aq. phosphate buffer;
at 22 ℃;
for 32h;
pH=7;
Time;
enantioselective reaction;
Catalytic behavior;
Flow reactor;
Enzymatic reaction;
|
96% |
|
With
D-glucose; broth E. coli HB101; pNTS1G; NADP;
In
various solvent(s);
at 30 ℃;
for 20h;
pH=6.5;
Enzymatic reaction;
|
95% |
|
With
hydrogen;
bis(acetato){(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl}rutenium(II);
In
methanol;
at 100 ℃;
for 1.5h;
under 30400 Torr;
|
95% |
|
With
bis(acetato){(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl}rutenium(II); hydrogen;
In
methanol;
at 100 ℃;
for 1.5h;
under 30402 Torr;
|
95% |
|
With
hydrogen;
bis(acetato){(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl}rutenium(II);
In
methanol;
at 100 ℃;
for 1.5h;
under 0.300024 Torr;
|
94% |
|
With
[RuCl2((R)-P-Phos)](DMF)n; hydrogen;
In
ethanol; dichloromethane;
at 96 ℃;
for 14h;
Autoclave;
|
94% |
|
With
Candida albicans NADPH-dependent reductase co-expressed with Bacillus megaterium glucose dehydrogenase in E. coli Rosetta (DE3) cell culture; Triton X-100;
In
acetic acid butyl ester;
at 30 ℃;
for 25h;
pH=6.2;
optical yield given as %ee;
enantioselective reaction;
aq. phosphate buffer;
Enzymatic reaction;
|
93.8% |
|
With
D-glucose; D-glucose dehydrogenase; Pichia guilliermondii; nicotinamide adenine dinucleotide phosphate; sodium hydroxide;
In
aq. phosphate buffer; dimethyl sulfoxide;
at 20 ℃;
for 3h;
pH=6.5;
Enzymatic reaction;
|
92% |
|
With
glucose dehydrogenase; pET28-bmgdh-dhcr; sodium carbonate;
In
aq. phosphate buffer; toluene;
at 30 ℃;
for 24h;
pH=6.5;
enantioselective reaction;
Kinetics;
Catalytic behavior;
Green chemistry;
Enzymatic reaction;
|
92.5% |
|
With
SmADH31;
Reagent/catalyst;
stereoselective reaction;
Kinetics;
Enzymatic reaction;
|
92% |
|
With
D-glucose;
In
phosphate buffer;
at 30 ℃;
for 12h;
pH=7;
|
90.1% |
|
With
D-glucose;
In
2,2,4-trimethylpentane; water;
at 30 ℃;
for 24h;
pH=7;
optical yield given as %ee;
aq. phosphate buffer;
Microbiological reaction;
Enzymatic reaction;
|
90% |
|
With
NAD; isopropyl alcohol;
In
aq. phosphate buffer;
at 30 ℃;
for 6h;
pH=7;
Reagent/catalyst;
stereoselective reaction;
Microbiological reaction;
Green chemistry;
Enzymatic reaction;
|
89% |
|
With
hydrogen;
C2H8N(1+)*C76H57Cl5O8P4Ru2(1-);
In
ethanol;
at 90 ℃;
for 2h;
autoclave;
|
88.5% |
|
With
nicotinamide-adenin-dinucleotide oxidized; magnesium chloride;
In
acetic acid butyl ester; isopropyl alcohol;
at 30 ℃;
for 8h;
optical yield given as %ee;
aq. phosphate buffer;
Enzymatic reaction;
|
88% |
|
With
D-(+)-glucose; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate;
In
aq. phosphate buffer;
at 30 ℃;
Reagent/catalyst;
Concentration;
|
87.2% |
|
With
ketoreductase; NADP;
In
acetic acid butyl ester; water;
for 7 - 18h;
pH=7;
|
87.4% |
|
With
recombinant carbonyl reductase from Streptomyces coelicolor; nicotinamide adenine dinucleotide; magnesium sulfate;
In
aq. phosphate buffer; isopropyl alcohol; toluene;
at 25 ℃;
for 24h;
pH=6.5;
pH-value;
Temperature;
stereoselective reaction;
Large scale;
Enzymatic reaction;
|
85.4% |
|
With
D-β-keto ester reductase (2); glucose 6-phosphate (G6P); glucose 6-phosphate dehydrogenase (G6PDH); NADPH;
at 30 ℃;
for 24h;
phosphate buffer (pH=7.0); other enzyme (D-β-keto ester reductase-1); in the presence of methyl vinyl ketone or ethyl chloroacetate;
|
84% |
|
With
D-β-keto ester reductase (2); glucose 6-phosphate (G6P); glucose 6-phosphate dehydrogenase (G6PDH); NADPH;
at 30 ℃;
for 24h;
phosphate buffer (pH 7.0);
|
84% |
|
With
Cylindrocarpon sclerotigenum IFO 31855; NADPH;
at 45 ℃;
for 1.5h;
pH=6.0;
|
64% |
|
With
glycerol dehydrogenase; 2-propanol-NAD(1+);
potassium phosphate buffer, pH 7;
|
55% |
|
With
Leifsonia sp. S749 cells alcohol dehydrogenase; nicotinamide adenine dinucleotide; isopropyl alcohol;
In
phosphate buffer;
at 25 ℃;
for 24h;
pH=7.0;
|
54% |
|
Daucas carota root; extract of;
In
water;
at 37 - 40 ℃;
for 60h;
pH=7.0;
Conversion of starting material;
Enzymatic reaction;
Aqueous phosphate buffer;
|
50% |
|
With
potassium phosphate buffer; carbonyl reductase from Candida magnoliae; NADPH;
at 37 ℃;
for 2h;
|
2.1% |
|
With
D-glucose 6-phosphate; α-acetoxy ketone reductase from bakers' yeast; MES buffer pH 6.0; NADPH; glucose 6-phosphate dehydrogenase;
at 35 ℃;
for 12h;
Rate constant;
|
|
|
With
D-glucose 6-phosphate; MES buffer pH 6.0;
at 35 ℃;
for 12h;
α-acetoxy ketone reductase from bakers' yeast, glucose 6-phosphate dehydrogenase, NADPH;
|
|
|
Cunninghamella echinulata CCT 4424;
In
phosphate buffer;
at 30 ℃;
pH=7;
Enzymatic reaction;
|
|
|
Cunninghamella echinulata CCT 4259;
In
phosphate buffer;
at 30 ℃;
pH=7;
Enzymatic reaction;
|
|
|
With
ammonium sulfate; potassium dihydrogenphosphate; baker's yeast harvested in log phase; magnesium sulfate; Sucrose;
for 24h;
|
|
|
RuCl(η6-p-cymene)((R)-BINAP)Cl;
In
ethanol; dichloromethane;
at 95 ℃;
for 0.5h;
under 76000 Torr;
|
|
|
With
broth of E. coli HB101 [pNtS1];
In
water; ethyl acetate;
at 30 ℃;
pH=6.5;
|
|
|
With
hydrogen;
Ru(R-Tol-P-Phos)(C6H6)Cl2;
In
ethanol; dichloromethane;
at 80 - 90 ℃;
for 2h;
under 15514.4 Torr;
|
|
|
With
potassium phosphate buffer; Cylindrocarpon sclerotigenum IFO 31855 carbonyl reductase; NADPH;
at 35 ℃;
pH=6.5;
|
|
|
With
glucose-6-phosphate dehydrogenase; α-D-glucose 6-phosphate; baker yeast YJR096w gene-pIK9 plasmid;
NAD;
at 30 ℃;
for 24h;
pH=7.0;
|
|
|
With
hydrogen;
Ru[chiral bis(trialkylphosphine)]Br2;
In
methanol; water;
at 100 ℃;
for 10h;
under 38000 Torr;
|
|
|
With
Candida magnoliae carbonyl reductase; D-glucose dehydrogenase; NADPH;
In
water; dimethyl sulfoxide;
at 20 ℃;
pH=6.5 - 6.6;
|
|
|
With
hydrogen;
[(RuCl{(R)-DIFLUORPHOS})2(μ-Cl)3][NH2Me2];
In
ethanol;
at 100 ℃;
for 3h;
under 75006 Torr;
|
|
|
With
hydrogen;
Ru((R)-biaryl diphosphine)Cl2(DMF)n;
In
ethanol; dichloromethane;
at 70 ℃;
for 24h;
under 2585.81 Torr;
|
|
|
With
1,4-dihydronicotinamide adenine dinucleotide;
In
phosphate buffer;
at 30 ℃;
pH=6.5;
Further Variations:;
Reaction partners;
Reagents;
Enzyme kinetics;
|
|
|
With
isopropyl alcohol;
nicotinamide adenine dinucleotide;
In
water;
at 25 ℃;
for 24h;
pH=7.0;
|
|
|
With
hydrogen;
ruthenium trichloride; (-)-5,5'-bis(diphenylphosphanyl)-2,2,2',2'-tetrafluoro-4,4'-bi[benzo-1,3-dioxolyl];
In
ethanol;
at 80 ℃;
for 2h;
under 3000.3 Torr;
|
97.6 % ee |
|
With
hydrogen;
5,5’-bis(diphenylphosphino)-4,4’-bi-1,3-benzodioxole; bis[(1-isopropyl-4-methylbenzene)dichloro ruthenium];
In
ethanol;
at 90 ℃;
for 2.3h;
under 22502.3 Torr;
|
89.5 % ee |
|
With
hydrogen;
C56H54I2P2Ru;
In
ethanol; dichloromethane;
at 100 ℃;
for 2.83333h;
under 16501.7 Torr;
|
97.4 % ee |
|
With
hydrogen;
C56H56BClF4P2Ru;
In
ethanol; dichloromethane;
at 100 ℃;
for 3h;
under 16501.7 Torr;
|
98.0 % ee |
|
With
hydrogen;
bis[(1-isopropyl-4-methylbenzene)dichloro ruthenium]; (-)-5,5'-bis(diphenylphosphanyl)-2,2,2',2'-tetrafluoro-4,4'-bi[benzo-1,3-dioxolyl];
In
ethanol; dichloromethane;
at 110 ℃;
for 1.16667h;
under 16501.7 Torr;
|
98.1 % ee |
|
With
hydrogen;
bis[(1-isopropyl-4-methylbenzene)dichloro ruthenium]; (-)-5,5'-bis(diphenylphosphanyl)-2,2,2',2'-tetrafluoro-4,4'-bi[benzo-1,3-dioxolyl];
In
ethanol;
at 90 ℃;
for 2.3h;
under 22502.3 Torr;
|
95.8 % ee |
|
With
hydrogen;
(+)-6-dicyclohexylphosphanyl-2'-diphenylphosphanyl-2-methoxy-1,1'-biphenyl; bis(1-isopropyl-4-methylbenzene)dichloro-ruthenium;
In
ethanol;
at 80 ℃;
for 3h;
under 3000.3 Torr;
Product distribution / selectivity;
|
80 % ee |
|
|
|
|
With
D-glucose;
In
water;
at 28 ℃;
for 24 - 48h;
Microbiological reaction;
|
|
|
With
ketoreductase from Candida magnoliae mutant CmKr10; NADPH;
at 20 ℃;
pH=7.6;
Reagent/catalyst;
Solvent;
optical yield given as %ee;
enantioselective reaction;
Kinetics;
aq. buffer;
Enzymatic reaction;
|
|
|
With
(+)-6-dicyclohexylphosphanyl-2'-diphenylphosphanyl-2-methoxy-1,1'-biphenyl; hydrogen;
bis(1-isopropyl-4-methylbenzene)dichloro-ruthenium;
In
ethanol;
at 80 ℃;
for 3h;
under 3000.3 Torr;
|
80 % ee |
|
With
hydrogen;
(+)-6-dicyclohexylphosphanyl-2'-diphenylphosphanyl-2-methoxy-1,1'-biphenyl; [RuCl2(p-cymene)2];
In
ethanol;
at 80 ℃;
for 3h;
under 3000.3 Torr;
Product distribution / selectivity;
|
80 % ee |
|
With
isopropyl alcohol;
at 37 ℃;
for 3h;
pH=6;
optical yield given as %ee;
enantioselective reaction;
aq. acetate buffer;
Enzymatic reaction;
|
|
|
With
D-glucose; water;
In
ethanol;
at 30 ℃;
for 18h;
optical yield given as %ee;
enantioselective reaction;
Enzymatic reaction;
|
|
|
With
recombinant stereospecific carbonyl reductase 1 from Candida parapsilosis; NAD;
In
aq. phosphate buffer;
at 30 ℃;
for 6h;
pH=6.5;
|
|
|
With
D-glucose; glucose dehydrogenase from Bacillus subtilis; β-ketoacyl-ACP reductase from Bacillus sp. ECU0013; NADP;
at 30 ℃;
for 12h;
pH=7;
optical yield given as %ee;
enantioselective reaction;
Kinetics;
aq. phosphate buffer;
Enzymatic reaction;
|
|
|
With
D-glucose; recombinant Saccharomyces cerevisiae alpha-keto amide reductase YDL124W; Thermoplasma acidophilum glucose dehydrogenase; NADPH;
at 25 ℃;
for 4h;
pH=6.5;
optical yield given as %ee;
enantioselective reaction;
aq. phosphate buffer;
Enzymatic reaction;
|
|
|
With
hydrogen;
[(R)P-Phos-Ru(benzene)Cl]Cl;
In
tetrahydrofuran; ethanol;
at 100 ℃;
for 2h;
under 18751.9 Torr;
Product distribution / selectivity;
|
98 % ee |
|
With
glucose dehydrogenase; D-glucose; (R)-specific alcohol dehydrogenase from Candida maris IFO10003; NADH;
In
dimethyl sulfoxide;
at 30 ℃;
for 17h;
pH=6.5;
optical yield given as %ee;
enantioselective reaction;
aq. phosphate buffer;
Enzymatic reaction;
|
|
|
With
glucose dehydrogenase; D-glucose; recombinant reductase CgKR2 from Candida glabrata; NADP; sodium carbonate;
at 30 ℃;
pH=6;
optical yield given as %ee;
enantioselective reaction;
aq. phosphate buffer;
Enzymatic reaction;
|
|
|
With
dichloro(benzene)ruthenium(II) dimer; carbon dioxide; hydrogen; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl;
at 75 ℃;
for 2h;
under 83605.6 Torr;
optical yield given as %ee;
enantioselective reaction;
Ionic liquid;
Inert atmosphere;
Autoclave;
|
|
|
With
Saccharomyces cerevisiae reductase R264H/S260E mutant; NADPH;
Reagent/catalyst;
Kinetics;
Enzymatic reaction;
|
|
|
With
(R)-alcohol dehydrogenase from Lactobacillus kefir DSM 20587;
In
aq. buffer;
at 30 ℃;
for 1h;
pH=7;
stereoselective reaction;
Enzymatic reaction;
|
> 99 % ee |
|
With
potassium phosphate; Candida parapsilosis aldo-keto reductase CPAR2; NADPH;
at 30 ℃;
for 8h;
pH=6.5;
enantioselective reaction;
Enzymatic reaction;
|
> 99.9 % ee |
|
With
D-glucose; nicotinamide adenine dinucleotide phosphate; recombinant Bacillus subtilis-derived glucose dehydrogenase; recombinant Gluconobacter oxydans carbonyl reductase 0525;
In
aq. phosphate buffer; ethanol;
at 30 ℃;
for 12h;
pH=7.0;
enantioselective reaction;
Kinetics;
Enzymatic reaction;
|
> 99 % ee |
|
With
glucose dehydrogenase; alpha-D-glucopyranose; BgADH2 enzyme; nicotinamide adenine dinucleotide phosphate;
In
water;
at 30 ℃;
pH=6.5;
Reagent/catalyst;
enantioselective reaction;
Enzymatic reaction;
|
> 99 % ee |
|
With
D-glucose; sodium carbonate;
In
aq. phosphate buffer; acetic acid butyl ester;
at 30 ℃;
for 5h;
pH=6.2;
enantioselective reaction;
Microbiological reaction;
Enzymatic reaction;
|
99 % ee |
|
With
Debaryomyceshansenii carbonyl reductase N179S/I214F/S215G; NADPH;
In
aq. phosphate buffer;
at 30 ℃;
for 2h;
pH=6.5;
Reagent/catalyst;
stereoselective reaction;
Enzymatic reaction;
|
>99 % ee |
|
With
aldo-keto reductase CaAKR; NADH;
In
aq. phosphate buffer;
at 30 ℃;
for 10h;
enantioselective reaction;
Enzymatic reaction;
|
> 99 % ee |
|
With
alpha-D-glucopyranose;
In
toluene;
at 50 ℃;
for 11h;
pH=5;
enantioselective reaction;
Kinetics;
Enzymatic reaction;
|
0.91% |
|
With
hydrogenchloride; dichloro-R-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl ruthenium; hydrogen;
In
methanol; water;
at 95 - 98 ℃;
under 6080.41 - 7600.51 Torr;
|
99.95 % ee |
|
With
sodium formate;
In
ethanol;
at 50 ℃;
Solvent;
Reagent/catalyst;
Temperature;
|
458 g |
|
With
NADP;
In
acetic acid butyl ester; water;
for 18h;
pH=6.8 - 7;
Product distribution / selectivity;
Aqueous phosphate buffer;
|
|
|
With
ketoreductase;
In
acetic acid butyl ester; water;
for 11h;
pH=7;
Product distribution / selectivity;
|
|
|
With
glucose dehydrogenase; ketoreductase;
In
acetic acid butyl ester; water;
at 13 ℃;
for 13h;
pH=7;
Product distribution / selectivity;
|
|
|
With
nicotinamide adenine dinucleotide phosphate; isopropyl alcohol;
In
dimethyl sulfoxide;
at 30 ℃;
for 24h;
pH=7.5;
enantioselective reaction;
Enzymatic reaction;
|
97 % ee |
-
-
638-07-3
ethyl (2-chloroaceto)acetate
-
-
10488-69-4,86728-85-0,87068-18-6,90866-33-4
ethyl (S)-4-chloro-3-hydroxybutanoate
-
-
10488-69-4,86728-85-0,87068-18-6,90866-33-4
ethyl (L)-4-chloro-3-hydroxybutyrate
Conditions
| Conditions | Yield |
|---|---|
|
With
D-glucose;
In
dodecane; water;
at 30 ℃;
for 24h;
pH=7;
optical yield given as %ee;
aq. phosphate buffer;
Microbiological reaction;
Enzymatic reaction;
|
89.3% |
|
With
D-glucose;
In
dodecane; water;
at 30 ℃;
for 24h;
pH=7;
optical yield given as %ee;
aq. phosphate buffer;
Microbiological reaction;
Enzymatic reaction;
|
10% |
|
In
water;
Product distribution;
bakers' yeast; addition of MgCl2; immobilization of bakers' yeast by magnesium alginate;
|
|
|
With
D-glucose; bakers' yeast; allyl alcohol;
In
water;
at 30 ℃;
for 24h;
Product distribution;
effect and amount of added allyl alcohol, stereoselectivity;
|
|
|
With
baker's yeast;
Product distribution;
stereospesifically, other γ-chloroacetoacetate esters;
|
|
|
With
adenine;
In
hexane;
at 30 - 35 ℃;
for 4h;
Product distribution;
immobilized Bakers' yeast (IBY); enantioselectivity with further additives;
|
|
|
With
D-glucose;
In
ethanol; water;
at 25 ℃;
for 48h;
Product distribution;
yeast Saccharomyces cerevisiae IFO 0565; yeast-mediated biochemical reduction of 3-oxoalkanoic esters, stereochemistry, enantiomeric excess;
|
|
|
With
immobilized D. carota cells; MS medium;
at 25 ℃;
for 5h;
Product distribution;
various ketones, enantioselective reduction;
|
|
|
With
glucose dehydrogenase; potassium phosphate buffer; D-glucose; air-dried cells of Pichia farinosa AKU4251; nicotinamide adenine dinucleotide phosphate; nicotinamide adenine dinucleotide;
at 28 ℃;
for 18h;
Product distribution;
Rate constant;
cells of other microorganisms, enantiomeric excess;
|
|
|
With
hydrogen;
bis(acetato){(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl}rutenium(II);
In
ethanol;
at 100 ℃;
for 0.0833333h;
under 76000.1 Torr;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
|
|
|
With
D-glucose; bakers' yeast; allyl alcohol;
In
water;
at 30 ℃;
for 24h;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
|
|
|
With
S. Cerevisiae mutant ATCC26403;
In
ethanol;
at 25 ℃;
for 72h;
Yield given. Yields of byproduct given;
|
|
|
With
allyl alcohol;
In
hexane;
at 30 - 35 ℃;
for 4h;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
immobilized Bakers' yeast (IBY);
|
|
|
With
D-glucose; allyl alcohol;
In
water;
at 30 ℃;
for 24h;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
raw bakers' yeast;
|
|
|
With
Ru<(S)-Ph,Ph-oxoProNOP>(OCOCH3)2; hydrogen;
In
dichloromethane;
at 20 ℃;
for 168h;
under 105008 Torr;
Title compound not separated from byproducts;
|
|
|
With
chloroacetic acid ethyl ester;
In
water;
for 4h;
Yield given. Yields of byproduct given;
Ambient temperature;
bakers' yeast;
|
|
|
With
sodium tetrahydroborate; L-Tartaric acid;
In
tetrahydrofuran;
at -20 ℃;
for 25h;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
|
|
|
With
hydrogen;
Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)};
In
ethanol;
at 100 ℃;
for 0.0833333h;
under 76000.1 Torr;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
|
|
|
In
water;
Yield given. Yields of byproduct given;
MgCl2, bakers' yeast immobilized by magnesium alginate;
|
|
|
With
hydrogen;
dichloro(benzene)ruthenium(II) dimer; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine);
In
ethanol;
at 100 ℃;
for 6h;
under 3040 Torr;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
|
|
|
With
S. Cerevisiae mutant ATCC26403;
In
ethanol;
at 25 ℃;
for 72h;
Yield given. Yields of byproduct given;
|
|
|
With
thioacetamide;
In
hexane;
at 30 - 35 ℃;
for 4h;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
immobilized Bakers' yeast (IBY);
|
|
|
With
(S)-BinapRuBr2; hydrogen;
In
ethanol;
at 93 ℃;
for 1h;
under 53200 Torr;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
|
|
|
With
glucose dehydrogenase; potassium phosphate buffer; D-glucose; air-dried cells of Sporobolomyces salmonicolor AKU4429; nicotinamide adenine dinucleotide phosphate; nicotinamide adenine dinucleotide;
at 28 ℃;
for 18h;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
|
|
|
Cunninghamella echinulata CCT 3140;
In
phosphate buffer;
at 30 ℃;
pH=7;
Title compound not separated from byproducts;
Enzymatic reaction;
|
|
|
With
baker's yeast; D-Glucono-1,5-lactone;
Title compound not separated from byproducts;
|
|
|
With
baker's yeast; allyl alcohol; Sucrose;
for 22h;
Title compound not separated from byproducts;
Ambient temperature;
|
|
|
With
baker's yeast; allyl alcohol; Sucrose;
for 19h;
Title compound not separated from byproducts;
Ambient temperature;
|
|
|
With
ruthenium trichloride; hydrogen; (S)-(-)-(6,6’-dimethoxybiphenyl-2,2’-diyl)bis(diphenylphosphine);
In
methanol;
at 120 ℃;
for 6h;
under 3000.24 Torr;
Title compound not separated from byproducts;
|
|
|
With
Saccharomyces cerevisiae;
In
water;
at 30 ℃;
for 20h;
|
|
|
With
hydrogen;
Ru(R-Xyl-P-Phos)(C6H6)Cl2;
In
ethanol; dichloromethane;
at 80 ℃;
for 2h;
under 15514.4 Torr;
Title compound not separated from byproducts;
|
|
|
With
hydrogen;
Ru[(R-BisbenzodioxanPhos)Cl2(DMF)n];
In
methanol;
at 80 - 90 ℃;
under 2585.74 Torr;
Title compound not separated from byproducts;
|
|
|
With
hydrogen bromide; hydrogen; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl;
[bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II);
In
ethanol;
at 110 ℃;
for 3h;
under 7500.6 Torr;
Title compound not separated from byproducts;
|
|
|
With
D-glucose; recombinant Pichia pastoris; NADP;
sodium hydroxide; sodium chloride;
In
various solvent(s);
at 30 ℃;
for 24h;
pH=7;
Title compound not separated from byproducts;
|
|
|
With
D-glucose; D-glucose dehydrogenase; recombinant ketoreductase;
NADPH;
In
phosphate buffer;
at 25 ℃;
pH=7.0;
Further Variations:;
Reagents;
Product distribution;
|
|
|
With
hydrogen;
[RuCl((S)-BINAP)(p-MeC6He(i-Pr)]Cl;
In
ethanol;
at 70 ℃;
for 1h;
under 9120 Torr;
Further Variations:;
Solvents;
Temperatures;
Catalysts;
Product distribution;
|
|
|
With
potassium phosphate buffer; Rhodotorula sp. AS22241;
at 30 ℃;
for 2h;
pH=7.0;
Title compound not separated from byproducts;
|
|
|
With
hydrogen;
Ru((S)-BINAP)Cl2(DMF)n;
In
dichloromethane;
at 70 - 100 ℃;
for 24h;
under 2585.74 Torr;
Further Variations:;
Catalysts;
Product distribution;
|
|
|
With
1,1-dicyclohexyl-2,2-diphenyldiphosphane; hydrogen;
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2;
In
ethanol;
at 80 ℃;
for 2h;
under 3000.24 Torr;
Further Variations:;
Reagents;
time;
Product distribution;
|
|
|
With
immobilized bakers' yeast;
In
water;
at 30 ℃;
|
|
|
With
immobilized bakers' yeast;
In
water;
at 30 ℃;
other substrate, other concentration;
|
|
|
With
Daucus carota root;
In
water;
at 20 ℃;
for 60h;
Title compound not separated from byproducts.;
|
|
|
With
chiral 1,5-diphenylphosphanylferrocene compound; hydrogen bromide; hydrogen;
[Ru(1,5-cyclooctadiene)(C4H7)2];
In
methanol;
at 50 ℃;
for 17h;
under 37503.8 Torr;
Further Variations:;
Reagents;
Product distribution;
|
|
|
With
hydrogen;
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2;
In
ethanol;
at 80 ℃;
for 4h;
under 3000.3 Torr;
Title compound not separated from byproducts.;
|
|
|
With
ketoreductase from Saccharomyces cerevisiae YglC; NADH;
at 20 ℃;
pH=7.6;
Reagent/catalyst;
Solvent;
optical yield given as %ee;
enantioselective reaction;
Kinetics;
aq. buffer;
Enzymatic reaction;
|
|
|
With
D-glucose; water; magnesium chloride;
In
ethanol;
at 30 ℃;
for 24h;
optical yield given as %ee;
enantioselective reaction;
Enzymatic reaction;
|
|
|
With
Saccharomyces cerevisiae;
at 30 ℃;
for 2h;
pH=7;
optical yield given as %ee;
enantioselective reaction;
aq. buffer;
|
|
|
With
(2S)-N-[(1R,2S)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]pyrrolidine-2-carboxamide; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; sodium formate;
In
water;
at 30 ℃;
for 20h;
optical yield given as %ee;
enantioselective reaction;
|
|
|
With
D-glucose;
In
ethanol;
at 25 ℃;
pH=6.8;
Reagent/catalyst;
optical yield given as %ee;
enantioselective reaction;
Kinetics;
Microbiological reaction;
aq. phosphate buffer;
|
|
|
(2,2'-bis(diphenylphosphino)-1,1'-binaphathalene)chloro(p-cymene)ruthenium chloride;
In
ethanol;
at 100 ℃;
for 4h;
under 30003 Torr;
Product distribution / selectivity;
|
|
|
With
(S)-alcohol dehydrogenase from Lactobacillus kefir DSM 20587;
In
aq. buffer;
at 30 ℃;
for 12h;
pH=7;
stereoselective reaction;
Enzymatic reaction;
|
60.2 % ee |
|
With
potassium phosphate; Candida parapsilosis aldo-keto reductase CPAR5; NADPH;
at 30 ℃;
for 8h;
pH=6.5;
enantioselective reaction;
Enzymatic reaction;
|
82.30 % ee |
|
With
potassium phosphate; Candida parapsilosis aldo-keto reductase CPAR6; NADPH;
at 30 ℃;
for 8h;
pH=6.5;
enantioselective reaction;
Enzymatic reaction;
|
11.84 % ee |
|
With
reductase from Rhodococcus sp. ECU1014; NADH;
In
aq. phosphate buffer;
pH=6;
Optical yield = 22 %ee;
Enzymatic reaction;
|
|
|
With
D-glucose; D-glucose dehyrodenase; Lodderomyces elongisporus aldo–keto reductase 48; NADPH;
In
aq. phosphate buffer;
at 30 ℃;
pH=7;
enantioselective reaction;
Enzymatic reaction;
|
70 % ee |
|
With
D-glucose; D-glucose dehyrodenase; Lodderomyces elongisporus aldo–keto reductase 49; NADPH;
In
aq. phosphate buffer;
at 30 ℃;
pH=7;
enantioselective reaction;
Enzymatic reaction;
|
58 % ee |
|
With
D-glucose; nicotinamide adenine dinucleotide phosphate; recombinant Bacillus subtilis-derived glucose dehydrogenase; recombinant Gluconobacter oxydans carbonyl reductase 0644;
In
aq. phosphate buffer; ethanol;
at 30 ℃;
for 12h;
pH=7.0;
enantioselective reaction;
Kinetics;
Enzymatic reaction;
|
21.6 % ee |
|
With
recombinant CR15 enzyme from Zygosaccharomyces rouxii;
enantioselective reaction;
Enzymatic reaction;
|
80.5 % ee |
|
With
[bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); 2′-(tert-butylmethylphosphanyl)biphenyl-2-yl camphanate; hydrogen bromide; hydrogen;
In
methanol;
at 80 ℃;
for 16h;
under 45004.5 Torr;
Overall yield = 61.5 %; enantioselective reaction;
Autoclave;
|
29 % ee |
|
With
glucose dehydrogenase; D-glucose; NADP+; carbonyl reductase LbCR;
In
aq. phosphate buffer;
at 30 ℃;
for 12h;
enantioselective reaction;
Enzymatic reaction;
|
91 % ee |
|
With
Kluyveromyces polysporus alcohol dehydrogenase S237R mutant; isopropyl alcohol; NADPH;
In
aq. phosphate buffer;
at 30 ℃;
pH=7;
Reagent/catalyst;
enantioselective reaction;
Enzymatic reaction;
|
88.8 % ee |
|
With
bis(1,5-cyclooctadiene)diiridium(I) dichloride; C26H25N2P; potassium tert-butylate; hydrogen;
In
isopropyl alcohol;
at 20 - 80 ℃;
for 24h;
under 38002.6 Torr;
Overall yield = 95 percent;
Inert atmosphere;
Autoclave;
|
2.What is the CAS number for Ethyl S-4-chloro-3-hydroxybutyrate ?
The CAS number of Ethyl S-4-chloro-3-hydroxybutyrate is 86728-85-0.
More information of Ethyl S-4-chloro-3-hydroxybutyrate 86728-85-0 are:
|
CAS?Number |
86728-85-0 |
|
Density |
1.187 g/cm3 |
|
Boiling Point |
263.4 °C at 760 mmHg |
|
Flash Point |
113.1 °C |
|
Vapor Pressure |
0.00145mmHg at 25°C |
|
Refractive Index |
n20/D 1.453(lit.) |
|
HS CODE |
29181990 |
|
PSA |
46.53000 |
|
LogP |
0.53930 |
|
Pka |
13.23±0.20(Predicted) |
3.What are another words for Ethyl S-4-chloro-3-hydroxybutyrate ?
Synonyms?for?Ethyl S-4-chloro-3-hydroxybutyrate 86728-85-0:Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate;
4.What is the molecular formula of Ethyl S-4-chloro-3-hydroxybutyrate?
The chemical formula of ?Ethyl S-4-chloro-3-hydroxybutyrate is?C6H11ClO3 which containing 6 Carbon atoms,11 Hydrogen atoms,1 Chlorine atoms and 3 Oxygen atoms,and the molecular weight of??Ethyl S-4-chloro-3-hydroxybutyrate?is 166.605.
5.What is Ethyl S-4-chloro-3-hydroxybutyrate (86728-85-0) used for?
Ethyl S-4-chloro-3-hydroxybutyrate is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutically relevant compounds. It is characterized by its unique structure, which includes a chiral center and a chlorine atom, making it a versatile building block for the development of new drugs.
InChI:InChI=1/C6H11ClO3/c1-2-10-6(9)3-5(8)4-7/h5,8H,2-4H2,1H3/t5-/m0/s1
Relevant articles related to Ethyl S-4-chloro-3-hydroxybutyrate:
|
Article |
Source |
|
Method for continuously preparing (R)-4-halo-3-hydroxy-butyrate by using micro-reaction system |
- Paragraph 0071-0093, (2021/02/10) |
|
Efficient Nicotinamide Adenine Dinucleotide Phosphate [NADP(H)] Recycling in Closed-Loop Continuous Flow Biocatalysis |
Baumer, Benedikt,Classen, Thomas,Pohl, Martina,Pietruszka, J?rg supporting information, p. 2894 - 2901 (2020/04/15) |
6.Buy Ethyl S-4-chloro-3-hydroxybutyrate with the best price .
Qingdao Spring Chemical Co.,Ltd. is a quality supplier of Ethyl S-4-chloro-3-hydroxybutyrate. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Ethyl S-4-chloro-3-hydroxybutyrate 86728-85-0.
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