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1,3-Dichloroisoquinoline

  • CAS：7742-73-6
  • purity：99%
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High Quality Chinese Factory supply 7742-73-6 1,3-Dichloroisoquinoline

  • Molecular Formula: C9H5Cl2N
  • Molecular Weight: 198.051
  • Appearance/Colour: white to brown crystalline powder 
  • Vapor Pressure: 0mmHg at 25°C 
  • Melting Point: 121-122 °C(lit.) 
  • Refractive Index: 1.661 
  • Boiling Point: 328.7 °C at 760 mmHg 
  • PKA: -1.49±0.50(Predicted) 
  • Flash Point: 182.6 °C 
  • PSA： 12.89000 
  • Density: 1.407 g/cm3 
  • LogP: 3.54160 

1,3-Dichloroisoquinoline(Cas 7742-73-6) Usage

General Description

1,3-Dichloroisoquinoline undergoes Pd(PPh3)4 catalyzed regioselective coupling with arylboronic acids to afford to 1-aryl-3-chloroisoquinolines. Reaction of amine with 1,3-dichloroisoquinoline has been studied. Regioselectivity of the Stille coupling reaction of (1-ethoxyvinyl)tri(n-butyl)stannane with 1,3-dichloroisoquinoline has been investigated.

InChI:InChI=1/C9H5Cl2N/c10-8-5-6-3-1-2-4-7(6)9(11)12-8/h1-5H

7742-73-6 Relevant articles

Axially chiral tridentate isoquinoline derived ligands for diethylzinc addition to aldehydes

Sweetman, Brian A.,Guiry, Patrick J.

, p. 5567 - 5581 (2018/08/09)

The synthesis and resolution of new trid...

SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

-

Page/Page column 136; 137, (2010/11/18)

The invention relates to substituted aro...

A facile synthesis of 1,3,4-trisubstituted isoquinolines

Yang, Hanbiao

body text, p. 3081 - 3083 (2009/10/04)

A facile and versatile approach to 1,3,4...

In vitro structure-activity relationship and in vivo characterization of 1-(aryl)-3-(4-(amino)benzyl)urea transient receptor potential vanilloid 1 antagonists

Perner, Richard J.,DiDomenico, Stanley,Koenig, John R.,Gomtsyan, Arthur,Bayburt, Erol K.,Schmidt, Robert G.,Drizin, Irene,Guo, Zhu Zheng,Turner, Sean C.,Jinkerson, Tammie,Brown, Brian S.,Keddy, Ryan G.,Lukin, Kurill,McDonald, Heath A.,Honore, Prisca,Mikusa, Joe,Marsh, Kennan C.,Wetter, Jill M.,St. George, Karen,Jarvis, Michael F.,Faltynek, Connie R.,Lee, Chih-Hung

, p. 3651 - 3660 (2008/02/12)

The synthesis and structure-activity rel...

7742-73-6 Process route

4H-isoquinolin-1,3-dione
4456-77-3

4H-isoquinolin-1,3-dione

1,3-dichloroisoquinoline
7742-73-6

1,3-dichloroisoquinoline

Conditions
Conditions Yield
With P,P-dichlorophenylphosphine oxide; at 130 ℃; for 2h;
79%
With P,P-dichlorophenylphosphine oxide; In tetrahydrofuran; water; at 20 - 160 ℃;
74%
With P,P-dichlorophenylphosphine oxide; at 160 ℃; for 3h; neat;
6.75 g
With P,P-dichlorophenylphosphine oxide;
9.30 g
With P,P-dichlorophenylphosphine oxide; at 160 ℃; for 4h;
2-cyanomethylbenzoic acid
6627-91-4

2-cyanomethylbenzoic acid

1,3-dichloroisoquinoline
7742-73-6

1,3-dichloroisoquinoline

Conditions
Conditions Yield
With phosphorus pentachloride; trichlorophosphate; In 2-cyanomethylbenzoic acid; at 20 - 70 ℃; for 17.5h;
84.5%

7742-73-6 Upstream products

  • 86-94-2
    86-94-2

    isoquinoline-1,3-diol

  • 53558-67-1
    53558-67-1

    2-phenethyl-4H -isoquinoline-1,3-dione

  • 10025-87-3
    10025-87-3

    trichlorophosphate

  • 4456-77-3
    4456-77-3

    4H-isoquinolin-1,3-dione

7742-73-6 Downstream products

  • 24649-22-7
    24649-22-7

    1-Chloro-3-methoxyisoquinoline

  • 119-65-3
    119-65-3

    isoquinoline

  • 19493-45-9
    19493-45-9

    3-chloroisoquinoline

  • 7742-74-7
    7742-74-7

    3-chloro-1-hydroxyisoquinoline

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