Nimesulide

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1.What is the Nimesulide ?

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50s = 1.27 and 0.03 μM for the human and ovine enzymes, respectively). It is selective for COX-2 over COX-1 (IC50s = 70 and 22 μM for the human and ovine enzymes, respectively). Nimesulide also inhibits sodium-dependent neutral amino acid transporter (B0AT1) with an IC50 value of 23 μM for the rat kidney transporter. It inhibits infection-induced increases in brain prostaglandin E2 (PGE2; ) levels, as well as reduces pyresis (ED50 = 0.3 mg/kg), in yeast-infected rats. Nimesulide (2.9 mg/kg) inhibits formalin-induced hindpaw thermal hyperalgesia in rats.

2.What is the CAS number for Nimesulide ?

The CAS number of Nimesulide is 51803-78-2.

3.What are another words for Nimesulide ?

Synonyms?for?Nimesulide 51803-78-2:4'-Nitro-2'-phenoxymethansulfonanilid;Methanesulfonamide,N-(4-nitro-2-phenoxyphenyl)-;4-Nitro-2-phenoxy-methanesulfonanilide;Aulin;Flogovital;N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide;

4.What is Nimesulide (51803-78-2) used for?

Nimesulide is a selective inhibitor of COX-2. The IC50 values are 70 and 1.27 μM for human recombinant COX-1 and -2 (at 20 μM arachidonic acid), respectively, and 22 and 0.03 μM for ovine COX-1 and -2 (at 100 μM arachidonic acid), respectively.[Cayman Chemical]

InChI:InChI=1/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3

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