EPZ011969

Chemical plants supply high-quality EPZ011969 1598383-40-4 in bulk We provide high quality EPZ011969 (CAS 1598383-40-4), at a very affordable prices to our customers.

1.What is the EPZ011969 ?

The lysine methyltransferase EZH2 (KMT6), part of polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 and is involved in proliferation and aggressive cell growth associated with neoplastic cells. EPZ011989 is an orally bioavailable EZH2 inhibitor with Ki values that are less than 3 nM for wild type and Tyr646 mutated EZH2. It displays 15-fold selectivity for EZH2 over EZH1 and is without effect against an array of other lysine methyltransferases. EPZ011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma.

N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]-benzamide is used in biological studies as inhibitors of EZH2 histone methyltransferase for the treatment of cancer.

2.What is the CAS number for EPZ011969 ?

The CAS number of EPZ011969 is 1598383-40-4.

More information of EPZ011969 1598383-40-4 are:

3.What is the molecular formula of EPZ011969 ?

The chemical formula of?EPZ011969 is C35H51N5O4 which containing 35 Carbon atoms,51 Hydrogen atoms,5 Nitrogen atoms and 4 Oxygen atoms,and the molecular weight, and the molecular weight of EPZ011969 is 605.821

4.What is EPZ011969(1598383-40-4)used for?

The lysine methyltransferase EZH2 (KMT6), part of polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 and is involved in proliferation and aggressive cell growth associated with neoplastic cells. EPZ011989 is an orally bioavailable EZH2 inhibitor with Ki values that are less than 3 nM for wild type and Tyr646 mutated EZH2. It displays 15-fold selectivity for EZH2 over EZH1 and is without effect against an array of other lysine methyltransferases. EPZ011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma.

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5.Chemical plants supply high-quality EPZ011969 1598383-40-4 in bulk

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