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(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide

  • CAS：432531-71-0
  • purity：99%
Inquiry

Reputable manufacturer supply (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide 432531-71-0 in stock with high standard

  • Molecular Formula: C18H15N5O6S2
  • Molecular Weight: 461.479
  • PSA： 195.95000 
  • LogP: 4.00650 

432531-71-0 Relevant articles

Necrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein

Liao, Daohong,Sun, Liming,Liu, Weilong,He, Sudan,Wang, Xiaodong,Lei, Xiaoguang

, p. 333 - 337 (2014/03/21)

Through high-throughput screening of 200...

432531-71-0 Process route

(E)-3-(2-nitrothiophen-5-yl)propenoic acid
50868-70-7

(E)-3-(2-nitrothiophen-5-yl)propenoic acid

(2E)-N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide
1360614-48-7,432531-71-0

(2E)-N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: thionyl chloride / toluene / 5 h / 110 °C / Inert atmosphere
2: sodium hydrogencarbonate / toluene / 0 - 20 °C / Inert atmosphere; Molecular sieve
With thionyl chloride; sodium hydrogencarbonate; In toluene;
2-amino-3-methoxypyrazine
4774-10-1

2-amino-3-methoxypyrazine

(2E)-N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide
1360614-48-7,432531-71-0

(2E)-N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: pyridine / 0 - 60 °C / Inert atmosphere
2: sodium hydroxide / water / 4 h / 105 °C / Inert atmosphere
3: sodium hydrogencarbonate / toluene / 0 - 20 °C / Inert atmosphere; Molecular sieve
With sodium hydrogencarbonate; sodium hydroxide; In pyridine; water; toluene;

432531-71-0 Upstream products

  • 55785-89-2
    55785-89-2

    (E)-3-(5-nitrothiophen-2-yl)acryloyl chloride

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    Sulfalen

  • 50868-70-7
    50868-70-7

    (E)-3-(2-nitrothiophen-5-yl)propenoic acid

  • 4774-10-1
    4774-10-1

    2-amino-3-methoxypyrazine

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